Medicine/7.
Clinical medicine
Starodubtseva I.A. (PhD)
NN Burdenko Voronezh State Medical Academy
The role of antioxidants in the development
and
progression of knee osteoarthritis:
Discussion of the results of investigation
A number of foreign authors place strong emphasis on
the vitamin reserve in the development of osteoarthritis. Among all vitamins possessing antioxidant
activity they specify vitamin C.
Ascorbic acid is vital for
physiological and biochemical processes, enhancing the development of
connective tissue, the process of regeneration and healing. For this reason, examination of the ascorbic
acid reserve in the presence of osteoarthritis is so important.
The research detected the tendency for a decrease of the
majority of estimates despite the fact that the study was conducted in the
summer and autumn periods when vitamin C supply is sufficient. Principal reduction of the ascorbic acid
reserve in the patients with stage III osteoarthritis in comparison to the
patients with stage I and stage II osteoarthritis is indicative of the
long-standing vitamin C deficiency within this population resulting in the
progression of osteoarthritis.
Low vitamin C reserve serves a
detrimental estimate in predicting the risk of the onset and progression of
osteoarthritis.
The low vitamin reserve in the osteoarthritic patients is due to a long-
standing vitamin C deficiency resulting in the disease progression and frequent
exacerbations.
In the course of treatment of osteoarthritic patients it is essential to
take into consideration their vitamin C reserve. Its level can determine the advance in therapy and further
prognosis for the development of the disease.
Contents of vitamin
C in patients with knee OA (M±m)
Table 1
Indicator |
Patients with knee ÎÀ (n=30) |
|
I – II stage (n=13) |
III stage (n=17) |
|
Vitamin Ñ (mg/dl) |
0,9±0,06* |
0,6±0,05* |
Pic. 1. Comparison evaluation of vitamin C concentration in
serum of patients with knee OA and healthy persons (* - p<0,001).
References
1. Kraus V. Vitamin C Worsens Knee Osteoarthritis in
Animal Study /V. Kraus
[Ýëåêòðîííûé ðåñóðñ] http: //www.dukemednews.org/news/article.php?id=7640
2. Pattison D J Vitamin C and the risk of developing inflammatory polyarthritis:
prospective nested case-control study / D J Pattison [et al] // Annals of the
Rheumatic Diseases. – 2004. – Vol. 63. – P.843 – 847.
3. Prescott R. How
Vitamins Deficiencies And Joint pain Are Related / R. Prescott [Ýëåêòðîííûé
ðåñóðñ] http://www.health.as1.ru/en/health-and-fitness/news_2007-04-17-00-35-31974.
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