Medicine/7. Clinical medicine

 

Starodubtseva I.A. (PhD)

NN Burdenko Voronezh State Medical Academy

The role of antioxidants in the development

 and progression of knee osteoarthritis:

Discussion of the results of investigation

 

             A number of foreign authors place strong emphasis on the vitamin reserve in the development of osteoarthritis.  Among all vitamins possessing antioxidant activity they specify vitamin C.

           Ascorbic acid is vital for physiological and biochemical processes, enhancing the development of connective tissue, the process of regeneration and healing.  For this reason, examination of the ascorbic acid reserve in the presence of osteoarthritis is so important.

          The research detected the tendency for a decrease of the majority of estimates despite the fact that the study was conducted in the summer and autumn periods when vitamin C supply is sufficient.  Principal reduction of the ascorbic acid reserve in the patients with stage III osteoarthritis in comparison to the patients with stage I and stage II osteoarthritis is indicative of the long-standing vitamin C deficiency within this population resulting in the progression of osteoarthritis.

           Low vitamin C reserve serves a detrimental estimate in predicting the risk of the onset and progression of osteoarthritis.

          The low vitamin reserve in the osteoarthritic patients is due to a long- standing vitamin C deficiency resulting in the disease progression and frequent exacerbations.

           In the course of treatment of osteoarthritic patients it is essential to take into consideration their vitamin C reserve.  Its level can determine the advance in therapy and further prognosis for the development of the disease.

 

Contents of vitamin C in patients with knee OA (M±m)

                                                                                                              Table 1     

Indicator

Patients with knee ÎÀ (n=30)

I – II stage (n=13)

III stage (n=17)

      Vitamin  Ñ (mg/dl)

 

          0,9±0,06*

         0,6±0,05*

    * - p<0,001

 

 

Pic. 1. Comparison evaluation of vitamin C concentration in serum of patients with knee OA and healthy persons (* - p<0,001).

 

 

 

 

 

 

 

References

 

1. Kraus V.  Vitamin C Worsens Knee Osteoarthritis in Animal Study /V. Kraus

[Ýëåêòðîííûé ðåñóðñ] http: //www.dukemednews.org/news/article.php?id=7640

2.  Pattison D J  Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study / D J Pattison [et al] // Annals of the Rheumatic Diseases. – 2004. – Vol. 63. – P.843 – 847.

3. Prescott R. How Vitamins Deficiencies And Joint pain Are Related / R.  Prescott [Ýëåêòðîííûé ðåñóðñ] http://www.health.as1.ru/en/health-and-fitness/news_2007-04-17-00-35-31974. html