Bobkova S.A, Kushnir K.G., Kolbasina L.P
Chair of Dentistry (Postgraduate Education Division)
SI “Crimea State Medical University named after S. I. Georgievsky”
Changes of mixed saliva enzymatic
activity under the exposure of fixed prosthesis’ materials
The usage of dental implants
expanded indications to restoration of teeth alignment defects with fixed
implants, which gives us possibility to perform balanced prosthetic repair
without teeth dissection. The material compatibility condition becomes the most
primary problem for implants and tooth prosthesis made from different alloys.
This article is related to optimization of the fixed implant-supported
prostheses’ constructional materials’ choice.
53 persons were selected for
carrying out of investigation. Besides 15 almost healthy persons (norm) were
examined. The first group of 38 persons was composed of those whom were made
the prosthetic appliance with PFM prosthesis based on cobalt-chrome alloy
(Duceram). The second group of 15 persons was composed of those patients whom
were made the prosthetic appliance with the usage of nonmetal ceramic dental prostheses.
Prosthetic alignment was carried out by two stage implant procedure using
“U-Impl” endosteal titanium screw implants with the further restoration using
different permanent constructions.
Inside the investigated groups were segregated 2 subdivisions (19 persons in the first group and 8 persons in the second group), which were everyday intramuscular injected in gluteus with 1 ml single-dose of the “Erbisolum” immunomodifier and antioxidant. The duration of therapeutic course comprises of 10 days.
Antioxidant potency of mixed saliva
was measured by the property of biomaterial to inhibit oxidation-reduction rate
of Fe(2+)-2,6 - dichlorophenol-indophenol (DCPIP) system.
Table 1 |
1 |
2 |
3 |
4 |
5 |
6 |
Group of investigation |
Term of investigation (months) |
|||||
First group (PFM prosthesis based on CCA),
n=38. A – without usage of Erbisolum, n=19 B – with using of Erbisolum, n=19 |
0,037± 0,001 p>0,005 0,036± 0,002 p>0,05 |
0,045± 0,003 +36,4 p<0,001 0,044± 0,004 +33,3 p<0,01 |
0,051± 0,002 +54,5 p<0,001 0,042± 0,001 +27,2 p<0,05 |
0,047± 0,003 +42.4 p<0,001 0,040± 0,003 +21,2 p<0,05 |
0,036± 0,001 +9,0 p>0,05 0,035± 0,002 +6,0 p>0,05 |
0,034± 0,002 +3,0 p>0,05 0,033± 0,004 0 p>0,05 |
Second group (nonmetal ceramic prosthesis), n
= 15. A – without usage of Erbisolum, n=7 B – with using of Erbisolum, n=8 |
0,034± 0,004 p>0,05 0,036± 0,003 p>0,05 |
0,043± 0,002 +30,3 p<0,01 0,042± 0,002 +22,2 p<0,05 |
0,040± 0,002 +21,2 p<0,05 0,035± 0,004 +6,0 p>0,005 |
0,036± 0,003 +9,0 p>0,05 0,034± 0,002 +3,0 p>0,05 |
0,034± 0,002 +3,0 p>0,05 0,033± 0,003 0 p>0,05 |
0,034± 0,003 +3,0 p>0,01 0,033± 0,002 0 p>0,05 |
Control group n = 15 |
0,033± 0,002 |
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|
|
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Toward the first month of
investigations after the prosthetic repair changes were imperceptible and had imperceptible
slight static attribute (p>0,05) in relation to control group. Towards the
second month of investigations the cascade growth of mixed saliva enzymatic
activity was marked in all the investigated groups, but the most expressed
growth was in the first group, Table 1.
Toward the third month of
investigations in the subdivision A of group 1 progressive growth of mixed
saliva enzymatic activity was observable, which activity in comparison with control
group was increased on 54,5% (p<0,001), at same time in the subdivision B,
where “Erbisolum” immunomodifier was used, was registered the tendency to
decrease of mixed saliva enzymatic activity. In the second group of patients,
where were used nonmetal ceramic dental prostheses, in the subdivision A enzymatic activity of the mixed saliva was
higher than benchmark on 21,2% (p<0,05), and in the subdivision B where
“Erbisolum” was included in the structure of
multimodality therapy the growth of AOA equaled 6% thus acquiring
uncertain character in relation to control. Toward the fourth month of
investigations antioxidant activity in the first group, especially in the A
subdivision was on the high level. The same
time in the second group, both in A and B subdivisions mixed saliva enzymatic
activity had the slight static attribute (p>0,05).
Henceforth (5-6 month) levels of AOA
both in the first and in the second investigation groups converged to the
benchmark level.
In such a manner as the result of
handled investigation it’s possible to come to the conclusion that nonmetal
ceramic dental prostheses are the most comparable with titanium implants. Usage
of “Erbisolum” immunomodifier and antioxidant essentially improves adaptation
of organism during the postsurgical period and decreases the risk of
complications’ development.