*112647*

Медицина\8.Морфология

Kolesnyk Vladimyr

Bukovinian State Medical University

department of neurology, psychiatry and medical psychology

Chernivtsi, Ukraine

VASCULAR PLEXUS OF THE LATERAL VENTRICLE OF THE CEREBRUM IN HUMAN ONTOGENESIS

Actuality of the theme. According to the publications of scientific sources of the last five years the cerebral pathology of fetuses and newborns represent a topical problem of modern health protection and encourages researchers (morphologists) to carry out new scientific inquiries a normal development of the brain may be disturb under the influence of many factors that is stipulated by both a high sensitivity of the brain during critical periods of the development and by irreversibility of some consequences of such effects. Extreme manifestations of the action of different pathogenic factors are defects of the development of an organ that are not compatible with life or result in a steady decrease of the intellectual ability or invalidism.

Materials and research methods. The object of our research was establishing the consistent pattern of the development, structure and morphology of the vascular plexus of the lateral ventricles of the human brain at different stages of ontogenesis. The vascular plexuses of the lateral ventricles of the cerebrum of a human being aged from 12 weeks of the intrauterine development to 83 years served as the material for a research. Taking the necropsy material was performed during a postmortem examination of the diceased of diverse gender and age whose death ensued from diseases not associated with a cerebral lesion.

Results and discussions. The studies in question show that the vascular plexuses of the lateral ventricles of the brain are made up of the epithelium and connective tissue witt a great number of blood vessels. The villiferous and nonvilliferous parts of the plexuses are identified. The epithelium is represented by the latter being corroborated by the information of Emerich D.F.(2004), Dariy A.A.(2008). The stroma of the vascular plexus is composed of collagenic fibrils, protofiblils and fibers that are dipped into the ground substances .Fibroblasts are arranged here in groups and singly. Branches of the microcirculatory channel with a high complexity of organization ramify from the blood vessels of the tela of the vascular plexus. It has been established that the diameters of the microvessels undergo changes which correlate with changes of the plexus itself, taking place concurrently with the development of the brain. The measurements of the dimeters of the microvessels carried out by us show that the components of the microcirculatory channel reach maximum values in persons aged 16-20 years and continue keeping at practically the same level at the age randing from 20 to 58 years.

On increase of the diameter of the microvessels of the vascular plexus of the brain lateral ventricles occurs in a wave-like manner whith the presence of periods of a rapid and retarded growth. The development and growth of the capillary bed correlates with changes of the functional load of the vascular plexus.

It has been established morphometrically that the density of the capillary bed per unit of the area of the vascular plexus (1mm) changes appreciably with the advancement of age both in the vascular plexus itself and between the plexuses of the lateral ventricles. A major pert of the volume of the plexus is made up of the microcirculatory bed which, in fact, determines its function. The vessels have a tortuons passage, forming “loops” on their way, particularly at the margins of the plexus. Along the passage of the vessels and the sites of a ramification of the arteriols clasters of smooth muscular cells are located, forming prototypes of muffs. The presence of them, evedetly influences on the regulation of the amount of blood in the vascular plexus

Findings. Microvessels in ontogenesis undergo changes which correlate with changes of the plexus itself (that take place in it simultaneously with the development of the brain) and reflect functional loads of the vascular plexus. The diameters of the constituent parts of the microcirculatory channel of the vascular plexus of the lateral ventricles of the brain increase (p<0.01) in mature age as compared with the intrauterine period of the development 2.17 times.

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